Different Slants

Seeing the World from a New Angle

What Causes Depression?

Filed under: Uncategorized — Rick at 8:14 am on Thursday, July 31, 2008

Bob’s article describing his experience with depression has received more than the usual amount of attention.  So,  my interest that much greater when, while reading “Science News” I came across the feature “Sick and Down” about one of the causes of depression.

The story discusses a link between the immune system and depression.  Part of the biology of depression is reduced levels of serotonin in the brain. It seems that cytokines, an inflammitory protein produced by the immune system to fight infection, can cause this reduction.  It is reasoned that this is an evolutionary response to illness that is built into all mammals.  The advantage is a conservation of energy that aids the battle against the infection.

However, when inflammation is prolonged, or caused by stress (or diet?), sickness behavior can turn into depression.  Chronic illnesses such as MS, diabetes and cancer can lead to depression.  A new diagnostic category: “Major Depressive Disorder with Increased Inflammation” has been considered.

In addition to inflammation, certain drugs that increase immune response have been found to cause depression.  These include some drugs used in chemotherapy and for treating hepatitis C.  Other drugs that block cytokines seem to improve mood.

Battle Cry of the Anguished American Immigrant!….by Robert M. Katzman

To me, being an American is an idea.

A concept. An agreement of equals.

A willingness to tolerate the differences in others, and a celebration of the beauty of cultural diversity.

While maybe originally, ours was a government,

Of the Protestants, By the Protestants and For the Protestants”

We’re bigger than that today.  A numerically insignificant People like my own family, Jews, now represent less than 2% of the total American population, but I believe that our Constitution includes me when I read it. I don’t live in fear, here.

Soon, there will be more Moslems in America than Jews, but I don’t care.  They came here to escape the same killing chaos that brought my family here, as well as looking for a new start and a fair chance to become successful.  I welcome them.  Besides, when the hating is missing, they may remember that we’re linguistic cousins who speak two versions of the same Semitic language, as do the Assyrians, who are Christian Arabs.

I’m happy to live in a country where the African-American and Hispanic populations overwhelm my own culture, because diversity doesn’t threaten me.  I like living in a country where being different doesn’t limit you, like being Cypriot, Cambodian, Armenian, Ethiopean, Roma, Kazak, Slovakian or Bulgarian.  Or Chechen, Bosnian or Somali.

The prospect of learning Spanish because the ever evolving tide of immigration and history now favor Latin America is not intimidating, because it will soon be the principal “American” language and my grandchildren will speak it fluently and wonder why I’m inept at it, like my immigrant grandparents whom were native speakers of Yiddish and found English to be daunting.

Damn frustrating English, impossible to spell but so rich in variety for songwriters and poets, has only been the lingua franca of North America for about three hundred plus years.

A speck in time.

(Read on …)

Depression, Despair and the Human Voice………….by Robert M. Katzman

Filed under: Depression and Hope,Robert Katzman's Stories — Bob at 3:29 pm on Friday, July 4, 2008

(Author’s note: This story was originally written to assist my Rabbi in counseling people in our Illinois synagogue. I posted it after deciding its contents might possibly have a wider audience.

Since July 4th, 2008, it has become the single most viewed story I’ve ever written for this blog. Realizing this, to my surprise, I rewrote large parts of it on Sunday, 7/27/08 to give it greater clarity and to expand some thoughts I felt were too cryptic. I appreciate that so many people have connected with it, so I felt I owed them, my unseen readers, my giving the story a second look.  If this true story has meaning for you, please tell others about it.  Thank you.— Robert M. Katzman

 

My goal is to turn words into pictures.  To make it possible for people with no concept of clinical depression to comprehend what life is really like for people who live with that condition.  People like me.

 

So, I mined my life for some specific moments to try to convey the cold futureless world I lived in for over fifty years, before reluctantly accepting the possibility that new medications would change, literally change, my mind and make my life livable.  Not just livable, but worth living.  

 

Some people never get that far, and those are people you sometimes read about whom, in some cases, seem to have so much at their fingertips, so many resources, even a loving and supportive family, but none of whom were able to detect the subtle, deadly and progressive power of a simple chemical imbalance in a person’s brain.

 

Unlike so many illnesses with physical manifestations like coughing, fever, rashes, flu-like symptoms, loss of vision, hearing, heart problems, ulcers, anemia, osteoporosis and dementia, depression is silent.  Invisible to the eye.  About as obvious as a single blade of grass not moving, in a sea of meadow grass being raked by the wind.

To experience depression is a solitary experience.  No one can catch it from anyone who has it.  It may alienate family, friends and co-workers who believe that a person is unpredictably “moody” and someone who can dampen the festive atmosphere of any social event by simply showing up and being their grim, joyless uncommunicative selves.  Those kinds of outward symptoms serve only to deepen the pain of the depressed person and cause the subsequent reaction of others to them, to make their existing, self-fulfilling assumptions of their social unpopularity become reality.

 

(Author’s note: This story was originally written to assist my Rabbi in counseling people in our Illinois synagogue. I posted it after deciding its contents might possibly have a wider audience.

Since July 4th, 2008, it has become the single most viewed story I’ve ever written for this blog. Realizing this, to my surprise, I rewrote large parts of it on Sunday, 7/27/08 to give it greater clarity and to expand some thoughts I felt were too cryptic. I appreciate that so many people have connected with it, so I felt I owed them, my unseen readers, my giving the story a second look.  If this true story has meaning for you, please tell others about it.  Thank you.— Robert M. Katzman

My goal is to turn words into pictures.  To make it possible for people with no concept of clinical depression to comprehend what life is really like for people who live with that condition.  People like me.

So, I mined my life for some specific moments to try to convey the cold futureless world I lived in for over fifty years, before reluctantly accepting the possibility that new medications would change, literally change, my mind and make my life livable.  Not just livable, but worth living.

Some people never get that far, and those are people you sometimes read about whom, in some cases, seem to have so much at their fingertips, so many resources, even a loving and supportive family, but none of whom were able to detect the subtle, deadly and progressive power of a simple chemical imbalance in a person’s brain.

Unlike so many illnesses with physical manifestations like coughing, fever, rashes, flu-like symptoms, loss of vision, hearing, heart problems, ulcers, anemia, osteoporosis and dementia, depression is silent.  Invisible to the eye.  About as obvious as a single blade of grass not moving, in a sea of meadow grass being raked by the wind.

To experience depression is a solitary experience.  No one can catch it from anyone who has it.  It may alienate family, friends and co-workers who believe that a person is unpredictably “moody” and someone who can dampen the festive atmosphere of any social event by simply showing up and being their grim, joyless uncommunicative selves.  Those kinds of outward symptoms serve only to deepen the pain of the depressed person and cause the subsequent reaction of others to them, to make their existing, self-fulfilling assumptions of their social unpopularity become reality.

I speak only as one of the inflicted and not in any other capacity.  What I know, I learned by reading as much as I could to make solving my misery possible.  A person’s intellect doesn’t cease to function, but motivation can stop cold.  Mine did.

But I also learned that having an innate and irrepressible sense of humor, plus a solid central core of self-worth were as essential to my survival as microscopic white blood cells are to fighting equally invisible infections. Those two immeasurable assets in my life-long struggle with depression proved to be mighty weapons, until they too were overwhelmed by the progressive nature of the illness.  But it took half a century for that battle to be lost.

It is impossible to will or wish away one’s genes, and in my family, the force was very strong.  Both sides of my immediate family and grandparents possessed the capacity for depression. While I believe her witnessing a series of deadly pogroms in Poland in the early part of the previous century powerfully triggered my maternal grandmother’s depression, so many of my aunts and cousins have it that it must be as common to all of us as our dark brown eyes.  I wish it were as easy to remove an “infected” gene as an appendix.  Maybe someday.

(Read on …)